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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
Published on: February 7, 2019
2,4-Bis(4-eth-oxy-phen-yl)-3-aza-bicyclo-[3.3.1]nonan-9-one
Dong Ho Park1, V Ramkumar, P Parthiban
1Department of Biomedicinal Chemistry, Inje University, Gimhae, Gyeongnam 621 749, Republic of Korea.
Abstract:
The title compound, C(24)H(29)NO(3), exists in a twin-chair conformation with an equatorial orientation of the 4-eth-oxy-phenyl groups. The benzene rings are inclined to each other at an angle of 28.0 (1)°. In the crystal, weak C-H⋯O inter-actions link mol-ecules related by translation into chains along the b axis. The crystal packing exhibits π-π inter-actions between the benzene rings of neighbouring mol-ecules [centroid-centroid distance = 3.692 (3) Å].
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