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Updated: May 17, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
4-Dimethyl-amino-N'-(2-hy-droxy-4-meth-oxy-benzyl-idene)benzohydrazide methanol monosolvate
1College of Marine Sciences, Zhejiang Ocean University, Zhoushan 316000, People's Republic of China.
Abstract:
The asymmetric unit of the title compound, C(17)H(19)N(3)O(3)·CH(4)O, comprises two Schiff base mol-ecules and two methanol solvent mol-ecules. The Schiff base mol-ecules are approximately planar, with r.m.s. deviations from the planes defined by the non-H atoms of 0.107 and 0.154 Å, and with dihedral angles between the benzene rings of 4.49 (15) and 8.39 (15)°, respectively. This near-planarity is assisted by the formation of intra-molecular O-H⋯N hydrogen bonds in each mol-ecule. In the crystal, the components are linked by N-H⋯O and O-H⋯O hydrogen bonds to form chains along [010].
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