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Updated: May 17, 2026

Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
Published on: November 23, 2016
4-(Cyclo-propane-carboxamido)-benzoic acid
Zhong-Qiang Sun1, Zhen-Ya Ding, Zhi-Yu Shao
1College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, People's Republic of China.
Abstract:
In the title compound, C(11)H(11)NO(3), the dihedral angle between the benzene ring and the cyclo-propane ring is 63.2 (1)°. In the crystal, mol-ecules are linked through classical cyclic carb-oxy-lic acid O-H⋯O hydrogen-bond inter-actions [graph set R(2) (2)(8)] giving centrosymmetric dimers which are extended along the b-axis direction through amide N-H⋯O hydrogen-bond inter-actions, giving one-dimensional ribbon structures. Weak C-H⋯O inter-actions are also present in the structure.
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IUPAC Nomenclature of Carboxylic Acids
For acyclic saturated monocarboxylic acids, the longest hydrocarbon chain containing the –COOH carbon is identified as the parent chain. Then, the last -e of the parent hydrocarbon name is replaced with a suffix -oic acid.
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The IUPAC and common names of amides are derived from the parent carboxylic acid, by replacing the suffix “oic acid” and “ic acid,” respectively, with “amide.” In the following example, the IUPAC name ethanamide is derived from ethanoic acid, and the common name, acetamide, is obtained from acetic acid.
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The IUPAC and common names of acid halides are derived from the corresponding carboxylic acids, by changing “ic acid” to “yl halide.” For example, as shown below, the IUPAC name ethanoyl chloride is derived from ethanoic acid, and the common name, acetyl chloride, is obtained from acetic acid.
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