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Obtaining 3D Chemical Maps by Energy Filtered Transmission Electron Microscopy Tomography

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Published on: June 9, 2018

An analytical method for computing voxel S values for electrons and photons.

Ernesto Amato¹, Fabio Minutoli, Massimiliano Pacilio

¹Department of Radiological Sciences, University of Messina, Messina, Italy. eamato@unime.it

Medical Physics

|November 7, 2012

Summary

This study presents a general method to calculate voxel S values (VSVs) for targeted radionuclide therapy dosimetry. The approach enables VSV determination for various electron and photon energies and voxel sizes, improving radiation dose calculations.

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Area of Science:

Medical Physics
Nuclear Medicine
Radiation Dosimetry

Background:

Voxel S values (VSVs) are crucial for radiation dosimetry with nonuniform activity distributions in organs or tumors.
Current VSV data is limited to specific voxel sizes and radionuclides, hindering broad clinical application.

Purpose of the Study:

To develop a generalized method for calculating VSVs for any electron and photon spectrum.
To enable VSV evaluation for any cubic voxel dimension relevant to clinical dosimetry in targeted radionuclide therapy.

Main Methods:

Monte Carlo simulations using Geant4 to determine energy deposited per disintegration (E(dep)) in soft tissue voxels.
Evaluation of monoenergetic electrons (10-2000 keV) and photons (10-1000 keV) across voxel sizes from 3 mm to 10 mm.
Development of parametric functions and interpolation methods to derive VSVs for various energies and voxel dimensions.

Main Results:

E(dep) showed smooth variations with energy and voxel size for both electrons and photons.
Parametric functions and interpolation allowed derivation of VSVs for monoenergetic emissions.
Integration enabled calculation of S values for continuous beta decay spectra.

Conclusions:

The developed method allows for the determination of VSVs for monoenergetic electrons and photons through interpolatable functions.
The approach can be generalized to continuous beta spectra, facilitating VSV calculations for diverse electron and photon emitters in voxelized structures.
This method enhances the accuracy and applicability of dosimetry in targeted radionuclide therapy.