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Chronic carotid glomitis and the glomus pulmonale
Journal of Clinical Pathology
|January 1, 1990
Summary
Chronic glomitis, an inflammation of glomera, affects both carotid bodies and the glomus pulmonale. This study found evidence of chronic pulmonary glomitis occurring independently or with carotid glomitis in older adults.
Area of Science:
- Pathology
- Histology
- Immunology
Background:
- The carotid bodies are well-known sites for chronic glomitis.
- The occurrence of chronic glomitis in the glomus pulmonale is less understood.
Purpose of the Study:
- To investigate whether chronic glomitis is exclusive to carotid bodies or also present in the glomus pulmonale.
- To characterize the prevalence and associations of chronic glomitis in both locations.
Main Methods:
- Histological examination of carotid bodies and glomus pulmonale.
- Analysis of 50 consecutive necropsy subjects over 50 years of age.
Main Results:
- Lymphoid aggregates and plasma cell activity, indicative of chronic inflammation, were observed in the glomus pulmonale.
- Chronic pulmonary glomitis was found in association with, and independently of, chronic carotid glomitis.
- Chronic carotid glomitis affected 14% of subjects, predominantly women. Isolated pulmonary glomitis also showed female predominance.
Conclusions:
- Chronic glomitis is not confined to the carotid bodies and can affect the glomus pulmonale.
- This inflammatory process involves at least two components of the non-chromaffin paraganglionic system.
- The reasons for focal chronic inflammation in the glomus pulmonale remain unclear.
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