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Big pharma screening collections: more of the same or unique libraries? The AstraZeneca-Bayer Pharma AG case
Thierry Kogej1, Niklas Blomberg, Peter J Greasley
1Chemistry Innovation Centre/Discovery Sciences, AstraZeneca R&D Mölndal, SE-43183 Mölndal, Sweden.
Abstract:
In this study, the screening collections of two major pharmaceutical companies (AstraZeneca and Bayer Pharma AG) have been compared using a 2D molecular fingerprint by a nearest neighborhood approach. Results revealed a low overlap between both collections in terms of compound identity and similarity. This emphasizes the value of screening multiple compound collections to expand the chemical space that can be accessed by high-throughput screening (HTS).
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