Adenosiland: walking through adenosine receptors landscape.

Area of Science:

• Pharmacology
• Bioinformatics
• Structural Biology

Background:

• Adenosine receptors (ARs) are G protein-coupled receptors regulated by adenosine, a widespread signaling molecule.
• Four subtypes (A1, A2A, A2B, A3) exist and are involved in diverse physiological and pathological processes.
• ARs are widely distributed in the human body with varying tissue-specific expression densities.

Purpose of the Study:

• To introduce Adenosiland, an integrated bioinformatics and chemoinformatics web-resource for adenosine receptors.
• To provide structure-based and ligand-based query functions for exploring ARs.
• To detail the platform's valuable searching tools and functionalities.

Main Methods:

• Development of an integrated web-resource combining bioinformatics and chemoinformatics approaches.
• Implementation of structure-based query functions for ARs.
• Implementation of ligand-based query functions for ARs.

Main Results:

• Adenosiland provides comprehensive tools for exploring adenosine receptor structures, from primary sequences to 3D architectures.
• The platform facilitates the exploration of structure-activity relationships for AR ligands.
• Adenosiland offers a user-friendly interface for accessing diverse information on adenosine receptors.

Conclusions:

• Adenosiland is a valuable, freely accessible resource for researchers studying adenosine receptors.
• The platform enhances the exploration of ARs through integrated bioinformatics and chemoinformatics tools.
• Adenosiland supports research into the physiopathological roles of adenosine receptors and the development of related therapeutics.