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Rhinosinusitis and asthma-microbiome and new perspectives
Harumi Suzaki1, So Watanabe, Ruby Pawankar
1Department of Otorhinolaryngology, Showa University School of Medicine, Tokyo, Japan. h-suzaki@med.showa-u.ac.jp
Current Opinion in Allergy and Clinical Immunology
|November 7, 2012
Summary
The human microbiome, particularly gut bacteria, influences immune responses relevant to asthma and allergic diseases. Further research is needed to understand the microbiome
Area of Science:
- * Human health research
- * Airway diseases
- * Microbiome and immune system
Background:
- * The hygiene hypothesis links environmental microorganisms to human health.
- * Gut microbiota regulate immune cells (Th1, Th2, Th17, Treg) and Toll-like receptors, impacting asthma and allergies.
- * Reduced environmental biodiversity may impair microbiota's immunomodulatory capacity.
Purpose of the Study:
- * To review the role of the microbiome in asthma and allergic diseases.
- * To explore the under-investigated relationship between the microbiome and chronic rhinosinusitis (CRS).
- * To highlight the connection between asthma and CRS, particularly CRS with nasal polyps (CRSwNP).
Main Methods:
- * Literature review of studies on microbiome, asthma, and allergic diseases.
- * Analysis of research on the gut microbiome's role in immune regulation.
- * Examination of studies linking nasal cavity microorganisms to CRS.
Main Results:
- * Established link between gut microbiome and immune cells relevant to asthma and allergies.
- * Evidence suggests a connection between nasal cavity microbes (e.g., Staphylococcus aureus) and CRS.
- * The relationship between the gut microbiome and CRS remains largely undetermined.
Conclusions:
- * The microbiome plays a significant role in asthma and allergic diseases.
- * CRS, especially CRSwNP, is associated with Th2-dominant immune responses.
- * Further studies on environmental microbial exposure in at-risk populations are crucial for understanding CRS development.
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