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Per3 VNTR polymorphism and chronic heart failure

Jolana Lipkova1, Julie Anna Bienertova-Vasku, Lenka Spinarova

  • 1Institute of Pathological Physiology, Faculty of Medicine, Masaryk University Brno, Czech Republic.

Biomedical Papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia
|November 7, 2012
PubMed

Insights

The Period3 (Per3) variable number tandem repeat (VNTR) polymorphism does not appear to be a significant risk factor for developing chronic heart failure (CHF). This genetic variation also did not influence the severity of CHF in the studied Caucasian population.

Area of Science:

  • Genetics
  • Cardiology
  • Molecular Biology

Background:

  • Chronic heart failure (CHF) is a complex condition with various contributing factors.
  • Genetic polymorphisms are increasingly investigated for their role in disease susceptibility and progression.

Purpose of the Study:

  • To examine the association between the Period3 (Per3) gene variable number tandem repeat (VNTR) polymorphism and the risk of developing chronic heart failure (CHF).
  • To determine if Per3 VNTR polymorphism influences the severity of CHF in affected individuals.

Main Methods:

  • Genotyping of Per3 VNTR polymorphism in 372 Caucasian patients with CHF and 332 healthy controls using allele-specific PCR.
  • Statistical analysis including genotype and allele frequency comparisons, and multivariate regression modeling.

Main Results:

  • No significant differences in Per3 VNTR genotype or allele frequencies were observed between CHF patients and healthy controls.
  • No significant associations were found between Per3 VNTR polymorphism and CHF etiology (dilated cardiomyopathy vs. ischemic heart disease).
  • Multivariate regression analysis indicated no predictive role of Per3 VNTR polymorphism for ejection fraction, NYHA class, hyperlipidemia, or type II diabetes risk.

Conclusions:

  • The Per3 VNTR polymorphism is not identified as a major genetic risk factor for chronic heart failure in the studied population.
  • This genetic variation does not appear to modulate the clinical severity of chronic heart failure.
Abstract

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