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The relationship between vitamin D deficiency and thoracic aortic dilatation

M Demir1, U Uyan, M Melek

  • 1Department of Cardiology, Bursa Yüksek İhtisas Education and Research Hospital, Bursa, Turkey. drmehmetmd@gmail.com

VASA. Zeitschrift Fur Gefasskrankheiten
|November 7, 2012
PubMed

Insights

Vitamin D deficiency is linked to thoracic aortic dilatation (TAD). Lower vitamin D levels and higher parathormone (PTH) levels were observed in TAD patients, indicating a significant association.

Area of Science:

  • Cardiology
  • Endocrinology
  • Vascular Biology

Background:

  • Vitamin D deficiency is implicated in cardiovascular diseases like hypertension and heart failure.
  • It can activate the renin-angiotensin-aldosterone system, impacting cardiovascular health.
  • A potential link between vitamin D deficiency and thoracic aortic dilatation (TAD) warrants investigation.

Purpose of the Study:

  • To investigate the association between 25-OH vitamin D levels and thoracic aortic dilatation (TAD).
  • To compare vitamin D and parathormone (PTH) levels in patients with and without TAD.

Main Methods:

  • The study included 87 patients with TAD and 93 controls, aged 40-70.
  • Transthoracic echocardiography was performed, and 25-OH vitamin D and PTH levels were measured.
  • Logistic regression analysis identified independent predictors of TAD.

Main Results:

  • Patients with TAD had significantly higher PTH levels (94.87 ± 44.96 pg/ml) compared to controls (66.39 ± 30.58 pg/ml).
  • TAD patients exhibited lower 25-OH vitamin D levels (11.89 ± 7.54 ng/ml) than controls (15.98 ± 4.98 ng/ml).
  • Both PTH and 25-OH vitamin D levels were found to be independent predictors of TAD.

Conclusions:

  • Vitamin D deficiency is an independent factor associated with thoracic aortic dilatation (TAD).
  • The findings suggest a role for vitamin D status in the pathogenesis of TAD.
Abstract

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