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Long-term benefits of home-based preventive care for preterm infants: a randomized trial
Megan M Spencer-Smith1, Alicia J Spittle, Lex W Doyle
1Critical Care and Neurosciences, Murdoch Childrens Research Institute, Victoria, Australia. megan.spencer-smith@mcri.edu.au
Insights
A home-based program for very preterm infants demonstrated long-term benefits, significantly reducing caregiver anxiety and preschooler internalizing behaviors by age 4.
Area of Science:
- Neonatal care
- Developmental pediatrics
- Parental mental health
Background:
- Previous findings showed benefits at 2 years for a home-based preventive program for very preterm infants.
- This study evaluated the longer-term effectiveness up to preschool age.
Purpose of the Study:
- To determine the long-term effectiveness of a home-based preventive care program for very preterm infants and their caregivers.
- To assess child functioning and caregiver mental health at 4 years corrected age.
Main Methods:
- 120 very preterm infants (<30 weeks gestation) were randomized to intervention or standard care.
- Intervention included 9 home visits in the first year, targeting infant development, parent mental health, and parent-infant relationship.
- Child cognitive, behavioral, motor functioning, and caregiver mental health were assessed at 4 years corrected age.
Main Results:
- No significant differences in cognitive or motor functioning between groups.
- Intervention group showed significantly lower child internalizing behaviors (P=.02).
- Intervention group caregivers reported fewer anxiety symptoms (P=.01) and were less likely to be at-risk for anxiety (P=.01).
Conclusions:
- The home-based preventive program offers selective long-term benefits for very preterm infants.
- Key long-term benefits include reduced caregiver anxiety and fewer internalizing behaviors in preschoolers.
- This highlights the sustained positive impact of early home-based interventions.
Background:
We have previously reported improved caregiver mental health and infant behavior at 2 years following a home-based preventive care program for very preterm infants and their caregivers. This study aimed to determine the longer-term effectiveness of the program by reviewing caregivers and children at preschool age.
Methods:
One hundred twenty very preterm infants (<30 weeks' gestation) were randomly allocated to intervention (n = 61) or control (n = 59) groups. The intervention included 9 home visits over the first year of life targeting infant development, parent mental health, and the parent-infant relationship. The control group received standard care. At 4 years' corrected age, child cognitive, behavioral, and motor functioning and caregiver mental health were assessed.
Results:
At age 4 years, 105 (89%) children were reviewed. There was little evidence of differences in cognitive or motor functioning between groups. The intervention group had lower scores for child internalizing behaviors than the control group (mean difference -5.3, 95% confidence interval [CI] -9.6 to -0.9, P = .02). Caregivers in the intervention group had fewer anxiety symptoms (mean difference -1.8, 95% CI -3.3 to -0.4, P = .01) and were less likely to exhibit "at-risk" anxiety (odds ratio 0.3, 95% CI 0.1 to 0.7, P = .01) than those in the control group.
Conclusions:
This home-based preventive care program for very preterm infants has selective long-term benefits, including less caregiver anxiety and reduced preschooler internalizing behaviors.
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