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High density lipoproteins, insulin secretion and coronary risk factors in latent coronary insufficiency
Insights
This study found no significant difference in high-density lipoprotein (HDL) cholesterol between men with and without preclinical coronary heart disease (CHD). Physical activity correlated with HDL, while inactivity linked to higher insulin secretion.
Area of Science:
- Cardiology
- Metabolic Syndrome
- Preventive Medicine
Background:
- Preclinical coronary heart disease (CHD) risk factors require further investigation in asymptomatic individuals.
- Understanding the interplay of metabolic markers and early CHD is crucial for effective prevention strategies.
Purpose of the Study:
- To investigate risk factors for preclinical coronary heart disease (CHD) in presumably healthy middle-aged men.
- To examine the relationship between high-density lipoprotein (HDL) cholesterol, insulin secretion, and other metabolic parameters in relation to early CHD detection.
Main Methods:
- Assessment of CHD risk factors in a cohort of presumably healthy men.
- Coronary angiography performed on subjects with "latent CHD" to evaluate for angiographic changes.
- Analysis of high-density lipoprotein (HDL) cholesterol, apoproteins, insulin secretion, glucose tolerance, serum triglycerides, and body weight.
Main Results:
- No significant differences in HDL cholesterol or apoproteins were observed between men with and without preclinical CHD.
- HDL cholesterol showed a positive correlation with physical activity.
- Insulin secretion was positively associated with physical inactivity, increased body weight, and higher serum triglycerides.
- Men with the highest insulin secretion exhibited the lowest glucose tolerance.
Conclusions:
- The study confirms the established covariance between HDL cholesterol, insulin secretion, serum triglycerides, body weight, and physical activity.
- The findings do not support the hypothesis that HDL cholesterol is a major negative risk factor in middle-aged men with preclinical CHD.
Abstract:
Coronary heart disease (CHD) risk factors were studied in presumably healthy men, examined for preclinical CHD. Coronary angiography was performed in most "latent CHD" subjects. High density lipoprotein (HDL) cholesterol and apoproteins did not differ significantly between men with latent CHD (some with angiographic changes) and men without evidence of CHD. HDL cholesterol was positively correlated with physical activity. Insulin secretion was, however, positively associated with physical inactivity, body weight and serum triglycerides. Men with the highest insulin secretion had the lowest glucose tolerance. The study confirms the covariance between HDL cholesterol, insulin secretion, serum triglycerides, body weight and physical activity, but does not support the theory that HDL is a major "negative risk factor" in middle-aged men with preclinical CHD.