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Updated: May 17, 2026

Direct Force Measurements of Subcellular Mechanics in Confinement using Optical Tweezers
Published on: August 31, 2021
Periodic modulations of optical tweezers near solid-state membranes
Gautam V Soni1, Magnus P Jonsson, Cees Dekker
1Delft University of Technology, Faculty of Applied Sciences, Kavli Institute of NanoScience, Department of Bionanoscience, Lorentzweg 1, 2628 CJ Delft, The Netherlands.
Abstract:
Optical tweezers operated near solid-state membranes show unexplained periodic modulations in the optical trap position. An experimental study of the oscillations is presented, as well as optical simulations based on the finite-difference time-domain method, providing insight into the underlying interference phenomenon. This work provides a complete description as well as a solution to the enduring problem of modulations in optical traps near solid-state membranes.

