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Published on: January 16, 2013
Strain-specific induction of experimental autoimmune prostatitis (EAP) in mice
Christopher M Jackson1, Dallas B Flies, Claudio A Mosse
1Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Background:
Prostatitis, a clinical syndrome characterized by pelvic pain and inflammation, is common in adult males. Although several induced and spontaneous murine models of prostatitis have been explored, the role of genetic background on induction has not been well-defined.
Methods:
Using a standard methodology for the induction of experimental autoimmune prostatitis (EAP), we investigated both acute and chronic inflammation on several murine genetic backgrounds.
Results:
In our colony, nonobese diabetic (NOD) mice evinced spontaneous prostatitis that was not augmented by immunization with rat prostate extract (RPE). In contrast, the standard laboratory strain Balb/c developed chronic inflammation in response to RPE immunization. Development of EAP in other strains was variable.
Conclusions:
These data suggest that Balb/c mice injected with RPE may provide a useful model for chronic prostatic inflammation.
