Related Experiment Video

Updated: May 17, 2026

System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis
09:57

System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis

Published on: April 5, 2017

A Comparative Study of MTA Solubility in Various Media

Mohammad Ali Saghiri1, Jack Ricci, Morteza Daliri Joupari

  • 1Department of Dental Material, School of Dentistry, Islamic Azad University of Medical sciences, Tehran, Iran.

Iranian Endodontic Journal
|November 7, 2012
PubMed
Abstract

Insights

Mineral trioxide aggregate (MTA) showed lower solubility in synthetic tissue fluid compared to deionized water. This indicates acceptable solubility for MTA root filling material in both environments.

Area of Science:

  • Biomaterials Science
  • Dental Materials Research
  • Endodontics

Background:

  • Root filling material solubility is significantly affected by the surrounding environment.
  • Understanding solubility is crucial for material longevity and clinical success.

Purpose of the Study:

  • To compare the solubility of ProRoot MTA in deionized water versus synthetic tissue fluid.
  • To evaluate the influence of different immersion media on MTA's physical properties.

Main Methods:

  • Forty ProRoot MTA specimens were immersed in deionized water or synthetic tissue fluid (20 each).
  • Solubility was assessed by weight loss after 7 and 28 days.
  • Scanning electron microscopy (SEM) was used to examine surface morphology.

Main Results:

  • MTA exhibited significantly lower solubility in synthetic tissue fluid compared to deionized water (P<0.05) at both time points.
  • SEM revealed surface lumps and platelets, with more voids observed in specimens stored in deionized water.
  • Weight loss analysis confirmed differential solubility based on the immersion medium.

Conclusions:

  • ProRoot MTA demonstrates reduced solubility in synthetic tissue fluid, suggesting better stability in a physiological environment.
  • The solubility of MTA in both deionized water and synthetic tissue fluid was deemed acceptable for clinical applications.
  • Environmental factors play a critical role in the dissolution behavior of endodontic sealers.
Keywords:
MediaMineral Trioxide AggregateSolubility

More Related Videos

Mapping Molecular Diffusion in the Plasma Membrane by Multiple-Target Tracing (MTT)12:19

Mapping Molecular Diffusion in the Plasma Membrane by Multiple-Target Tracing (MTT)

Published on: May 27, 2012

Related Concept Videos

Factors Affecting Solubility04:01

Factors Affecting Solubility

Compared with pure water, the solubility of an ionic compound is less in aqueous solutions containing a common ion (one also produced by dissolution of the ionic compound). This is an example of a phenomenon known as the common ion effect, which is a consequence of the law of mass action that may be explained using Le Chȃtelier’s principle. Consider the dissolution of silver iodide:
Solubility Equilibria: Overview01:09

Solubility Equilibria: Overview

When a substance such as sodium chloride is added to water, it dissolves, forming an aqueous solution. The extent of dissolution is called solubility. The process of dissolution can exist in equilibrium, just like other chemical processes. Solubility equilibria are also called precipitation equilibria because the process of solubility can be reversible. The reverse of the solubility process is called precipitation.
Solubility is important in biological and environmental processes. A notable...
Solubility Equilibria03:07

Solubility Equilibria

Solubility equilibria are established when the dissolution and precipitation of a solute species occur at equal rates. These equilibria underlie many natural and technological processes, ranging from tooth decay to water purification. An understanding of the factors affecting compound solubility is, therefore, essential to the effective management of these processes. This section applies previously introduced equilibrium concepts and tools to systems involving dissolution and precipitation.
The...
Noncompartmental Analysis: Mean Transit, Absorption and Dissolution Time01:02

Noncompartmental Analysis: Mean Transit, Absorption and Dissolution Time

When drugs are administered extravascularly, a comprehensive evaluation through noncompartmental analysis becomes imperative. This analytical approach considers various parameters that play a crucial role in understanding the pharmacokinetics of these drugs.
One of the key parameters is the mean transit time (MTT), which refers to the total duration required for drug molecules to transit through the body. MTT is determined by calculating the ratio of the area under the moment curve to the area...
Solubility of Ionic Compounds02:55

Solubility of Ionic Compounds

Solubility is the measure of the maximum amount of solute that can be dissolved in a given quantity of solvent at a given temperature and pressure. Solubility is usually measured in molarity (M) or moles per liter (mol/L). A compound is termed soluble if it dissolves in water.
Physical Properties Affecting Solubility02:19

Physical Properties Affecting Solubility

Solutions of Gases in Liquids
As for any solution, the solubility of a gas in a liquid is affected by the attractive intermolecular forces between solute and solvent species. Unlike solid and liquid solutes, however, there is no solute-solute intermolecular attraction to overcome when a gaseous solute dissolves in a liquid solvent since the atoms or molecules comprising a gas are far separated and experience negligible interactions. Consequently, solute-solvent interactions are the sole...