Related Experiment Video
Updated: May 17, 2026
Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
Published on: December 20, 2024
Clinico-etiological study with response to specific treatment in childhood urticaria
Surender Pal Gupta1, Nidhi Jindal, Sanjeev Gupta
1Department of Pediatrics, MM Institute of Medical Sciences and Research, Mullana, Ambala, India.
Insights
Infections are the most common cause of childhood urticaria, including acute and chronic forms. This study investigated etiological factors and treatment responses in pediatric patients with this common skin condition.
Area of Science:
- Pediatric Dermatology
- Immunology
Background:
- Urticaria is a frequent dermatological issue in adults, but chronic urticaria (CU) is less common in children.
- Limited data exists on pediatric urticaria etiology, necessitating further research.
Purpose of the Study:
- To identify etiological factors contributing to urticaria in pediatric patients.
- To assess treatment responses in children diagnosed with urticaria.
Main Methods:
- Retrospective analysis of 80 pediatric patients (ages 1-14) with urticaria.
- Evaluation included detailed history, physical examination, laboratory investigations, and specific in vivo/in vitro tests.
Main Results:
- Infection was the most frequent underlying cause of urticaria in children.
- Thyroid dysfunction was noted in 12 patients; 2 had positive thyroid anti-peroxidase antibodies.
- Autologous serum skin test was positive in 17 patients.
Conclusions:
- Infections represent the primary etiological factor for pediatric urticaria.
- Further research is needed to fully understand the diverse causes of urticaria in children.
Background:
Urticaria is a common dermatological manifestation in adults with relatively infrequent occurrence of chronic urticaria (CU) in childhood. The etiology of urticaria in childhood remains incompletely understood because of limited data on children.
Objective:
We carried out this retrospective data-based study to determine different etiological factors and response to treatment in pediatric patients presenting with urticaria.
Materials And Methods:
EIGHTY CHILDREN (M : F 49 : 31) between the ages of 1 and 14 years, who presented with urticaria excluding patients of physical urticaria attending the Outpatient Department of Pediatrics and Dermatology were included in the study. Patients were evaluated after taking a detailed history, doing a thorough physical examination, and basic laboratory investigations. Specific in vivo and in vitro tests were performed after the initial evaluation and consent of patients.
Results:
Out of eighty patients, 35 (43.75%) presented with acute urticaria and 45 (56.25%) gave a history of chronic urticaria.CU. An underlying cause was suspected in 53 cases (66.25%), although a definite association with response to a specific treatment was correlated in 30 (37.5%). Infection was the most common underlying causative factor. Underlying thyroid dysfunction was observed in 12 patients, of whom two had thyroid anti peroxidase antibodies. Autologous serum skin test was positive in 17 patients.
Conclusions:
In the present study infections were the most common etiological factor for urticaria in children.
Related Concept Videos
01:30Hypersensitivities
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
01:30Drug Toxicity: Allergic Reactions
02:06Allergic Reactions
01:30Allergic Reactions: Anaphylaxis
01:19Hypersensitivity Reactions: Immune-Complex Reactions
01:25Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...