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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Loss of Tumor Suppressor Gene Functions01:12

Loss of Tumor Suppressor Gene Functions

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
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Cells of the Epidermis01:24

Cells of the Epidermis

The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...

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Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
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Pilomatricoma: Forget me not.

Lakshmi Narayan Garg1, Sanjay Arora, Sunita Gupta

  • 1Department of Otolaryngorhinology, MM Institute of Medical Sciences and Research, Mullana, Ambala, India.

Indian Dermatology Online Journal
|November 7, 2012
PubMed
Summary

Pilomatricoma, a benign skin tumor, is often misdiagnosed. This case highlights the importance of considering pilomatricoma in superficial skin tumor differentials for accurate diagnosis.

Keywords:
Benign tumorneckpilomarixomapilomatricoma

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Area of Science:

  • Dermatology
  • Surgical Pathology

Background:

  • Pilomatricoma is a rare benign skin neoplasm.
  • Diagnosis is frequently delayed until after histopathological examination.

Observation:

  • A 30-year-old woman presented with a neck swelling.
  • The swelling was surgically excised.
  • Post-operative histopathology confirmed the diagnosis of pilomatricoma.

Findings:

  • Pilomatricoma is underdiagnosed in clinical practice.
  • Clinical suspicion is often lacking due to the neoplasm's rarity and variable presentation.
  • Histopathological confirmation is the gold standard for diagnosis.

Implications:

  • Dermatologists and surgeons should include pilomatricoma in the differential diagnosis of superficial skin tumors.
  • Increased awareness can lead to earlier and more accurate diagnoses.
  • Prompt diagnosis and surgical excision ensure benign outcomes for pilomatricoma.