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Related Concept Videos

Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
Acute Pyelonephritis I: Introduction01:27

Acute Pyelonephritis I: Introduction

Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such as Proteus,...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Gastritis III: Clinical Manifestations and Management01:23

Gastritis III: Clinical Manifestations and Management

The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...

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Related Experiment Videos

Pyoderma gangrenosum: An update.

Ramesh M Bhat1

  • 1Department of Dermatology, Venereology and Leprosy, Fr Muller Medical College, Kankanady, Mangalore, India.

Indian Dermatology Online Journal
|November 7, 2012
PubMed
Summary
This summary is machine-generated.

Pyoderma gangrenosum (PG) is a rare skin condition causing ulcers. Diagnosis relies on clinical signs, and treatment involves corticosteroids and immunosuppressants, with new therapies emerging.

Keywords:
Corticosteroidspyoderma gangrenosumulcerative

Related Experiment Videos

Area of Science:

  • Dermatology
  • Immunology
  • Internal Medicine

Background:

  • Pyoderma gangrenosum (PG) is an uncommon, idiopathic cutaneous ulceration.
  • Its pathogenesis remains poorly understood, though it can be linked to systemic disorders.
  • Clinical presentations include ulcerative, pustular, bullous, and vegetative types, with rare variants.

Purpose of the Study:

  • To review the clinical characteristics, diagnostic criteria, and management of Pyoderma gangrenosum.
  • To highlight the diagnostic challenges and the role of clinical recognition.
  • To discuss current and emerging treatment strategies for PG.

Main Methods:

  • Review of clinical features and classification of Pyoderma gangrenosum.
  • Discussion of diagnostic criteria and supportive investigations.
  • Overview of therapeutic approaches, including corticosteroids, immunosuppressants, and novel agents.

Main Results:

  • Diagnosis is primarily based on characteristic clinical evolution.
  • Investigations play a supportive role rather than a primary diagnostic one.
  • Treatment typically involves immunosuppression, with ongoing research into new modalities.

Conclusions:

  • Pyoderma gangrenosum diagnosis is predominantly clinical.
  • Effective management requires a combination of corticosteroids and immunosuppressive agents.
  • Emerging treatments offer new hope for managing this complex condition.