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Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists

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Updated: May 17, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Endothelin-1 in systemic sclerosis.

Mehrdad Aghaei¹, Farhad Gharibdost, Habib Zayeni

¹Department of Rheumatology, Faculty Member of Golestan University of Medical Sciences, Tehran, Iran.

Indian Dermatology Online Journal

|November 7, 2012

Summary

This summary is machine-generated.

Systemic Sclerosis (SSc) patients with digital ulcers have higher Endothelin-1 (ET-1) levels. This suggests ET-1 contributes to vascular damage, fibrosis, and skin thickening in SSc.

Keywords:

Digital ulcer endothelin scleroderma

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Area of Science:

Rheumatology
Dermatology
Vascular Biology

Background:

Scleroderma, or Systemic Sclerosis (SSc), is a systemic autoimmune disease of unknown cause.
Characterized by skin thickening and potential organ damage.
Endothelin-1 (ET-1) is implicated in the pathogenesis of skin fibrosis in SSc.

Purpose of the Study:

To investigate and compare plasma Endothelin-1 (ET-1) levels in Systemic Sclerosis (SSc) patients.
To assess differences in ET-1 levels between SSc patients with and without digital ulcers.

Main Methods:

A cross-sectional analytical study involving 95 SSc patients.
Data collected via questionnaires and plasma ET-1 level measurements.
Statistical analysis performed using SPSS software.

Main Results:

A significant correlation was found between digital ulcers/pitting scars and plasma ET-1 levels (P < 0.05).
No significant relationship was observed between patient age and plasma ET-1 levels.

Conclusions:

Plasma ET-1 levels are elevated in SSc patients who develop digital ulcers compared to those without.
Increased ET-1 may play a role in vascular damage, fibrosis, and skin thickening in SSc.