Related Experiment Video
Updated: May 17, 2026
07:11
Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
Published on: May 25, 2020
A combined index of structure and function for staging glaucomatous damage
Felipe A Medeiros1, Renato Lisboa, Robert N Weinreb
1Hamilton Glaucoma Center, Department of Ophthalmology, University of California, San Diego, CA 92093-0946, USA. fmedeiros@glaucoma.ucsd.edu
Archives of Ophthalmology (Chicago, Ill. : 1960)
|November 7, 2012
Summary
A new combined index of structure and function (CSFI) accurately detects glaucoma and differentiates disease stages. This glaucoma index combining structure and function outperforms individual measures for early and advanced visual field loss.
Area of Science:
- Ophthalmology
- Medical Imaging
- Glaucoma Research
Background:
- Glaucoma diagnosis and staging rely on structural and functional measures.
- Current methods may have limitations in early detection and differentiation of disease severity.
Purpose of the Study:
- To introduce and evaluate a novel Combined Structure and Function Index (CSFI).
- To assess the CSFI's efficacy in detecting and staging glaucomatous damage.
Main Methods:
- Observational study involving 333 glaucomatous and 330 healthy eyes.
- Utilized standard automated perimetry and spectral domain optical coherence tomography.
- Calculated CSFI based on estimated retinal ganglion cell (RGC) loss.
Main Results:
- Mean CSFI was significantly higher in perimetric (41%) and preperimetric (17%) glaucoma groups compared to healthy eyes.
- CSFI demonstrated superior performance over isolated structural or functional indices in receiver operating characteristic curve analysis.
- Effectively differentiated between early, moderate, and advanced stages of visual field loss.
Conclusions:
- The combined index (CSFI) integrating structure and function offers improved diagnostic capability for glaucoma.
- CSFI is a valuable tool for detecting both perimetric and preperimetric glaucoma.
- The index aids in discriminating various stages of glaucomatous disease progression.
