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Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...

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[DIETARY PREVENTION OF PROTEIN-ENERGY MALNUTRITION IN ELDERLY PATIENTS IN THE POSTOPERATIVE PERIOD].

Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology·2016
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[Enteral dysfunction as a factor of protein-energy insufficiency development in elderly persons following gastric surgery].

Advances in gerontology = Uspekhi gerontologii·2013
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Palatable Western-style Cafeteria Diet as a Reliable Method for Modeling Diet-induced Obesity in Rodents
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Palatable Western-style Cafeteria Diet as a Reliable Method for Modeling Diet-induced Obesity in Rodents

Published on: November 1, 2019

[Gerontodietology].

A Iu Baranovskiĭ, O B Protopopova

    Advances in Gerontology = Uspekhi Gerontologii
    |November 8, 2012
    PubMed
    Summary

    Gerontodietology focuses on nutrition for older adults and those at risk of aging. It outlines rational, prophylactic, and curative nutrition principles to optimize health and prevent age-related diseases.

    Area of Science:

    • Gerontology
    • Dietetics
    • Nutritional Science

    Background:

    • Gerontodietology addresses the unique nutritional needs of the elderly and those at risk of premature aging.
    • It explores principles of rational, prophylactic, and curative nutrition for this demographic.
    • Understanding these aspects is crucial for maintaining health and preventing pathological aging.

    Purpose of the Study:

    • To present the functional structure, scientific-methodical bases, and terminology of modern gerontodietology.
    • To detail the composition and features of healthy nutrition for the elderly, including optimization and individualization methods.
    • To describe geriatric dietotherapy and its distinction from other age groups, focusing on prophylactic gerontodietology for high-risk individuals.

    Main Methods:

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    Palatable Western-style Cafeteria Diet as a Reliable Method for Modeling Diet-induced Obesity in Rodents
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    Published on: November 1, 2019

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    Solid Plate-based Dietary Restriction in Caenorhabditis elegans

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  • Review and synthesis of existing knowledge in gerontodietology.
  • Detailed description of nutritional components and strategies for elderly populations.
  • Presentation of theoretical and methodological frameworks for prophylactic gerontodietology.

    • Main Results:

    • The study outlines the structure and principles of gerontodietology, emphasizing rational, prophylactic, and curative nutrition.
    • It provides detailed insights into healthy eating for the elderly, with methods for personalization.
    • Key differences between geriatric dietotherapy and general curative nutrition are highlighted.

    Conclusions:

    • Gerontodietology is essential for addressing the nutritional challenges of aging populations.
    • The principles of rational and prophylactic nutrition are vital for preventing age-related decline.
    • This field offers practical dietary strategies to mitigate involution processes and organic pathology.