Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

Cancer Stem Cells and Tumor Maintenance

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Conjunctivitis as a sign of persistent SARS-COV-2 infection? An observational study and report of late symptoms.

European journal of ophthalmology·2021

Same author

Vitamin D deficiency, secondary hyperparathyroidism and respiratory insufficiency in hospitalized patients with COVID-19.

Journal of endocrinological investigation·2021

Same author

Extending Human Papillomavirus (HPV) vaccination beyond female adolescents and after treatment for high grade CIN: the Italian HPV Study Group (IHSG) review and position paper.

European review for medical and pharmacological sciences·2020

Same author

HPV self-sampling in CIN2+ detection: sensitivity and specificity of different RLU cut-off of HC2 in specimens from 786 women.

Journal of clinical pathology·2016

Same author

Comparison of Onclarity Human Papillomavirus (HPV) Assay with Hybrid Capture II HPV DNA Assay for Detection of Cervical Intraepithelial Neoplasia Grade 2 and 3 Lesions.

Journal of clinical microbiology·2015

Same author

Circulating endothelial cell levels in psoriatic patients and their modification after an anti-TNF-alpha (Etanercept) treatment.

Journal of the European Academy of Dermatology and Venereology : JEADV·2013

Search research articles

Related Experiment Video

Updated: May 17, 2026

Circulating Tumor Cell Lines: an Innovative Tool for Fundamental and Translational Research

Circulating Tumor Cell Lines: an Innovative Tool for Fundamental and Translational Research

Published on: December 25, 2021

Single circulating tumor cell profiling: a new perspective for targeted therapy?

M C Cassatella¹, L Zorzino, M T Sandri

¹Laboratory Medicine Division, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy.

Future Oncology (London, England)

|November 8, 2012

Summary

Single cell profiling of circulating tumor cells (CTCs) offers insights into breast cancer metastasis. Analyzing CTCs aids in predicting relapse risk and treatment efficacy.

More Related Videos

Microfluidics-based High-throughput Circulating Tumor Cell Sorting and Single-cell Sequencing Technology

Microfluidics-based High-throughput Circulating Tumor Cell Sorting and Single-cell Sequencing Technology

Published on: November 14, 2025

Target Cell Pre-enrichment and Whole Genome Amplification for Single Cell Downstream Characterization

Target Cell Pre-enrichment and Whole Genome Amplification for Single Cell Downstream Characterization

Published on: May 15, 2018

Related Experiment Videos

Last Updated: May 17, 2026

Circulating Tumor Cell Lines: an Innovative Tool for Fundamental and Translational Research

Circulating Tumor Cell Lines: an Innovative Tool for Fundamental and Translational Research

Published on: December 25, 2021

Microfluidics-based High-throughput Circulating Tumor Cell Sorting and Single-cell Sequencing Technology

Microfluidics-based High-throughput Circulating Tumor Cell Sorting and Single-cell Sequencing Technology

Published on: November 14, 2025

Target Cell Pre-enrichment and Whole Genome Amplification for Single Cell Downstream Characterization

Target Cell Pre-enrichment and Whole Genome Amplification for Single Cell Downstream Characterization

Published on: May 15, 2018

Area of Science:

Oncology
Molecular Biology
Genomics

Background:

Circulating tumor cells (CTCs) are crucial for understanding cancer metastasis and patient prognosis.
CTCs may serve as early indicators of treatment efficacy and drug resistance.
Phenotypic changes in shed tumor cells during metastasis necessitate single-cell characterization.

Discussion:

This study evaluates single-cell profiling of circulating tumor cells (CTCs) in breast cancer patients.
It explores the transcriptional heterogeneity and diversity within these cells.
Identifying targets on single CTCs can inform therapeutic strategies and resistance monitoring.

Key Insights:

Single-cell analysis reveals significant heterogeneity among circulating tumor cells.
Transcriptional profiling of CTCs provides a deeper understanding of metastatic processes.
This approach holds potential for personalized medicine in breast cancer treatment.

Outlook:

Further research into single CTCs can refine prognostic models and guide treatment decisions.
Developing advanced techniques for CTC isolation and analysis is essential.
Single-cell profiling may lead to novel therapeutic targets for metastatic breast cancer.