Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Principles of Drug Action01:24

Principles of Drug Action

Drugs are chemical substances that modify biological responses by interacting with macromolecular targets such as receptors, ion channels, transporters, and enzymes. Pharmacodynamics describes the course of action of drugs leading to the physiological effect at a specific site in the body.
Drugs can be agonists or antagonists. Like the endogenous ligands, agonists always bind and activate the target to produce a cellular response. Agonist binding induces a conformational change which in turn...
Antipsychotic Drugs: Therapeutic Uses and Side Effects01:21

Antipsychotic Drugs: Therapeutic Uses and Side Effects

Antipsychotic drugs primarily block dopamine and serotonin receptors and cholinergic, adrenergic, and histaminergic receptors, thereby reducing hallucinations and delusions in conditions like schizophrenia. However, they can trigger unwanted extrapyramidal effects such as dystonias, Parkinson-like symptoms, and tardive dyskinesia.
Despite these side effects, antipsychotics are used therapeutically for various purposes, including managing schizophrenia, preventing nausea and vomiting, curbing...
Psychosis: Goals of Pharmacotherapy01:26

Psychosis: Goals of Pharmacotherapy

Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation. For...
Pharmacodynamics: Overview and Principles01:21

Pharmacodynamics: Overview and Principles

Pharmacodynamics is a scientific field that delves into drugs' intricate biochemical, cellular, and physiological effects on the human body. The study of pharmacodynamics helps us understand how drugs interact with the body and elicit various responses.
Most drugs' effects result from their interactions with drug receptors or targets within the body. These interactions trigger specific responses at the cellular or systemic level. Drug receptors can be found on the surfaces of cells or within...
Drug Therapy01:28

Drug Therapy

The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Cholinergic Antagonists: Therapeutic Uses01:26

Cholinergic Antagonists: Therapeutic Uses

Antimuscarinic drugs have various therapeutic applications by inhibiting parasympathetic stimulation in different systems. Here are the key therapeutic uses of antimuscarinics:    
Respiratory Tract: Ipratropium, aclidinium, and tiotropium treat asthma, chronic bronchitis, and chronic obstructive pulmonary disease (COPD). They protect against bronchoconstriction caused by irritants like cigarette smoke, sulfur dioxide, and ozone. They also help reduce nasopharyngeal secretions in common...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Identification of alpha1-oleate as a potent regulator of adipokine-dependent metabolism, in bladder cancer tissue.

Cancer & metabolism·2026
Same author

Targeting the disease response with NlpD and LytM for effective non-antibiotic treatment of urinary tract infections.

The Journal of infectious diseases·2026
Same author

Bacterial protein-oleate complexes induce ferroptosis-like cell death in colorectal cancer cells by disrupting cell membranes and inhibiting the β-catenin-GPX4 axis.

Cell death discovery·2026
Same author

<i>Filifactor alocis</i> FtxA blocks inflammation and apoptosis pathways in monocytic cells.

Frontiers in cellular and infection microbiology·2026
Same author

High-frequency Ultrasound Reveals Epidermal-dermal Structural Alterations in an Experimental Model of Epidermolysis Bullosa.

Acta dermato-venereologica·2026
Same author

Targeted innate immune inhibition therapy compared with antibiotics for recurrent acute cystitis: a randomized, open-label phase 2 trial.

Nature microbiology·2026
Same journal

Plain language summary of the MiroCIP study: how often chemotherapy-induced peripheral neuropathy happens in the first year of oxaliplatin- or taxane-based chemotherapy.

Future oncology (London, England)·2026
Same journal

Study of brentuximab vedotin combination treatment in people with early-stage Hodgkin lymphoma: a plain language summary.

Future oncology (London, England)·2026
Same journal

How enzalutamide affects sex life and how taking a break from treatment affects quality of life: a plain language summary of results from the EMBARK study in people with hormone-sensitive prostate cancer and high-risk biochemical recurrence.

Future oncology (London, England)·2026
Same journal

Physician perspectives on the decision-making process for patients with high-risk early-stage triple-negative breast cancer in a community oncology setting.

Future oncology (London, England)·2026
Same journal

Healthcare resource utilization and economic burden of metastatic pancreatic cancer: a US commercial and Medicare claims analysis.

Future oncology (London, England)·2026
Same journal

Disparities in mortality among HER2-positive breast cancer patients treated with trastuzumab in Chile (2015-2024): real-world evidence from 4,920 cases.

Future oncology (London, England)·2026
See all related articles

Related Experiment Video

Updated: May 17, 2026

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B
11:44

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

Published on: January 19, 2022

HAMLET: functional properties and therapeutic potential.

James Ho C S1, Anna Rydström, Maria Trulsson

  • 1Department of Microbiology, Immunology & Glycobiology (MIG), Institute of Laboratory Medicine, Lund University, Sölvegatan 23, S-223 62 Lund, Sweden.

Future Oncology (London, England)
|November 8, 2012
PubMed
Summary
This summary is machine-generated.

Human α-lactalbumin made lethal to tumor cells (HAMLET) selectively kills tumor cells by targeting conserved death pathways. This protein-lipid complex shows therapeutic potential in various cancers with no observed toxicity in normal tissues.

More Related Videos

Viability Assays for Cells in Culture
12:03

Viability Assays for Cells in Culture

Published on: January 20, 2014

Related Experiment Videos

Last Updated: May 17, 2026

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B
11:44

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

Published on: January 19, 2022

Viability Assays for Cells in Culture
12:03

Viability Assays for Cells in Culture

Published on: January 20, 2014

Area of Science:

  • Biochemistry
  • Cell Biology
  • Oncology

Background:

  • Human α-lactalbumin made lethal to tumor cells (HAMLET) is a novel protein-lipid complex.
  • α-lactalbumin normally functions in the lactose synthase complex.
  • Partial unfolding and binding to oleic acid induce HAMLET's tumoricidal activity.

Purpose of the Study:

  • To investigate the tumoricidal mechanism and therapeutic potential of HAMLET.
  • To identify cellular targets and pathways affected by HAMLET.
  • To evaluate HAMLET's efficacy and safety in preclinical cancer models.

Main Methods:

  • Characterization of HAMLET's structure-activity relationship.
  • Analysis of cellular responses to HAMLET treatment.
  • Assessment of HAMLET's therapeutic effects in human cancer models.

Main Results:

  • HAMLET exhibits broad tumoricidal activity by targeting conserved cell death pathways.
  • Sensitivity to HAMLET is linked to oncogene expression (Ras, c-Myc) and glycolytic enzymes.
  • HAMLET demonstrated therapeutic effects in human skin papillomas, bladder cancers, and glioblastomas without toxicity to normal tissues.

Conclusions:

  • HAMLET represents a promising new class of anti-cancer agents.
  • Targeting conserved tumor cell death pathways with HAMLET offers novel therapeutic avenues.
  • HAMLET's selective toxicity profile warrants further investigation for clinical application.