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Related Concept Videos

Anatomy of the Genitourinary System II: Bladder and Urethra01:19

Anatomy of the Genitourinary System II: Bladder and Urethra

The lower urinary system consists of the urinary bladder and urethra, which are essential in storing and expelling urine from the body. Together with the internal and external sphincters, these structures work together to regulate urination effectively.Anatomy of the BladderThe urinary bladder is a muscular, stretchable organ behind the pubic bone and in front of the rectum. In females, the bladder is positioned anterior to the vagina and inferior to the uterus, while in males, it is located...
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...
Urinary Tract Calculi III: Medical Management01:30

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The diagnosis of renal calculi involves several imaging techniques, including non-contrast CT scans and ultrasound. These methods help visualize kidney stones, assess their size and location, and detect possible obstructions. Additionally, Measuring urine pH is useful for diagnosing specific stone types, such as struvite (alkaline pH) and uric acid stones (acidic pH). Cystine stones are primarily linked to cystinuria, a genetic condition. A urinalysis helps detect blood in the urine (hematuria)...
Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care01:30

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A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
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The human urogenital system, once thought to be sterile in healthy individuals, is now recognized as a complex microbial habitat. Advancements in molecular sequencing techniques have revealed that even in healthy adults, the kidneys and bladder harbor microbial populations similar to those found in the distal urethra, albeit in much lower abundance. These resident microorganisms, while generally innocuous, can become opportunistic pathogens under conditions that alter the urogenital...

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Updated: May 17, 2026

Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing
05:25

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Published on: August 14, 2019

Gene therapy for lower urinary tract dysfunction.

Naoki Yoshimura1, Minoru Miyazato, Katsumi Sasaki

  • 1Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15206, USA. nyos@pitt.edu

International Journal of Urology : Official Journal of the Japanese Urological Association
|November 8, 2012
PubMed
Summary
This summary is machine-generated.

Gene therapy offers a promising new approach for treating refractory lower urinary tract dysfunction. This review explores the potential of gene therapy for the lower urinary tract and its afferent pathways.

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Last Updated: May 17, 2026

Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing
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Published on: August 14, 2019

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Area of Science:

  • Urology
  • Molecular Medicine
  • Neuroscience

Background:

  • Lower urinary tract dysfunction arises from complex alterations in organs and nervous systems.
  • Despite advances, many cases remain resistant to conventional treatments.
  • New therapeutic strategies are crucial for refractory lower urinary tract symptoms.

Purpose of the Study:

  • To review the current status and potential of gene therapy for lower urinary tract dysfunction.
  • To explore gene therapy as a novel approach for treatment-resistant cases.

Main Methods:

  • Literature review of recent research on lower urinary tract dysfunction.
  • Analysis of gene therapy applications targeting the lower urinary tract and afferent pathways.

Main Results:

  • Gene therapy presents a potential new avenue for managing refractory lower urinary tract dysfunction.
  • Understanding of underlying mechanisms has improved, leading to new drug development.

Conclusions:

  • Gene therapy holds significant promise for addressing unmet needs in lower urinary tract dysfunction.
  • Further research is warranted to fully realize the therapeutic potential of gene therapy in urology.