Related Experiment Video
Updated: May 17, 2026
09:30
Non-invasive Assessment of Changes in Corticomotoneuronal Transmission in Humans
Published on: May 24, 2017
Clinical implication of Meissner`s corpuscles
Jose A Vega1, Alfonso López-Muñiz, Marta G Calavia
1Departamento de Morfología y Biología Celular, Facultad de Medicina, Universidad de Oviedo, C/ Julian Claveria 6, Oviedo, Spain. javega@uniovi.es
CNS & Neurological Disorders Drug Targets
|November 8, 2012
Summary
Skin biopsies can diagnose peripheral neuropathies by examining Meissner
Area of Science:
- Neuroscience
- Dermatology
- Pathology
Background:
- Skin biopsy is increasingly used for diagnosing peripheral neuropathies.
- Research has primarily focused on intraepithelial nerve fibers, neglecting other skin structures.
- Quantitative and qualitative changes in Meissner's corpuscles in neurological disorders remain understudied.
Purpose of the Study:
- To comprehensively review Meissner's corpuscles.
- To explore their role in various pathologies.
- To advocate for their inclusion in routine skin biopsy analysis.
Main Methods:
- Literature review of Meissner's corpuscle research.
- Analysis of distribution, density, and age-related changes.
- Examination of molecular composition, anatomy, and physiology.
Main Results:
- Meissner's corpuscles exhibit specific distribution and density patterns.
- Age significantly impacts Meissner's corpuscle characteristics.
- Pathological changes in these corpuscles are linked to various disorders.
Conclusions:
- Meissner's corpuscles are valuable diagnostic markers in skin biopsies.
- Their analysis can aid in diagnosing peripheral and central nervous system disorders.
- Future research should focus on integrating Meissner's corpuscle evaluation into clinical practice.
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