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[Plasma D-dimer changes and prognostic implication in severe acute pancreatitis].
Hong-jun Wu1, Rong-xia Li, Yi Li
1Department of Emergency Medicine, Peking Union Medical College Hospital, Beijing, China.
Summary
Plasma D-dimer levels are elevated in patients with severe acute pancreatitis (SAP) and correlate with disease severity. Early D-dimer measurements effectively indicate the severity of SAP.
Area of Science:
- Biochemistry
- Hematology
- Clinical Medicine
Context:
- Severe acute pancreatitis (SAP) is a critical condition with significant morbidity and mortality.
- Early and accurate assessment of SAP severity is crucial for timely intervention and improved patient outcomes.
- Plasma D-dimer, a marker of coagulation activation, has been investigated for its potential role in SAP.
Purpose:
- To investigate the diagnostic and prognostic value of plasma D-dimer in patients with severe acute pancreatitis.
- To determine the relationship between plasma D-dimer levels and established severity scores (Ranson scores) and CT-based grading.
- To assess the correlation of plasma D-dimer with the development of multiple organ failure (MOF) in SAP.
Summary:
- A prospective study involving 32 SAP patients measured plasma D-dimer at multiple time points post-admission.
- Plasma D-dimer levels showed positive correlations with white blood cell count, creatinine, PT, and APTT, and negative correlations with hematocrit, albumin, and calcium.
- Elevated D-dimer levels at 48 hours correlated with higher Ranson scores, more severe CT grades (D, E), and the presence of MOF.
Impact:
- Plasma D-dimer is a valuable biomarker for assessing SAP severity.
- Early plasma D-dimer measurements can serve as an indicator of disease severity in SAP patients.
- These findings may aid in clinical decision-making and patient stratification in SAP management.
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