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Respiratory problems in acromegaly.

N J Murrant1, D J Gatland

  • 1Ear, Nose and Throat Department, St Bartholomew's Hospital, London.

The Journal of Laryngology and Otology
|January 1, 1990
PubMed
Summary
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Respiratory issues, including upper airway obstruction, are a significant concern in acromegaly, leading to increased mortality. This study highlights laryngeal obstruction as a critical, often overlooked, cause of respiratory compromise in acromegaly patients.

Area of Science:

  • Endocrinology
  • Pulmonology
  • Otolaryngology

Background:

  • Acromegaly, a disorder caused by excess growth hormone, is associated with a threefold higher mortality from respiratory causes compared to the general population.
  • Respiratory complications in acromegaly often stem from upper airway obstruction, but pulmonary dysfunction and central nervous system disturbances can also contribute.

Observation:

  • While macroglossia and pharyngeal hypertrophy are commonly cited causes of upper airway obstruction in acromegaly, laryngeal involvement is also reported.
  • This study details four cases where acromegaly patients required tracheostomy due to laryngeal obstruction.

Findings:

  • Laryngeal obstruction is a critical, though less frequently emphasized, cause of respiratory distress in acromegaly.
  • The combination of factors can lead to severe respiratory compromise, necessitating interventions like tracheostomy.

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Implications:

  • Increased awareness of laryngeal involvement in acromegaly is crucial for timely diagnosis and management of respiratory complications.
  • Further research into the mechanisms and effective treatments for acromegaly-related airway obstruction is warranted.
  • Improved understanding can reduce respiratory mortality in acromegaly patients.