Related Experiment Video
Updated: May 17, 2026

Growing a Cystic Fibrosis-Relevant Polymicrobial Biofilm to Probe Community Phenotypes
Published on: April 19, 2024
Exploring the parallel development of microbial systems in neonates with cystic fibrosis
Geraint B Rogers1, Kenneth D Bruce
1Institute of Pharmaceutical Science, Molecular Microbiology Research Laboratory, King's College London, London, United Kingdom.
Abstract:
Recent studies have greatly extended our understanding of the microbiota present in and on the human body. Here, advanced sequencing strategies have provided unprecedented analytical power. The important implications that the emerging data have for human health emphasize the need to intensify research in this area (D. A. Relman, Nature 486:194-195, 2012). It is already clear from these studies that the microbiotas characterized in different body locations of healthy individuals are both complex and diverse (The Human Microbiome Project Consortium, Nature 486:215-221). These studies also provide a point of contrast for investigations that aim to characterize the microbiota present in disease conditions. In this regard, Madan et al. (mBio 3(4):e00251-12, 2012) monitored the development over time of microbiota in the oropharynges and feces of neonates with cystic fibrosis and explored the potential for interactions between these complex microbial systems.
More Related Videos
Related Concept Videos
Development of the Oral Microbiota
Development of Human Microbiota
Cystic Fibrosis: Pathogenesis
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation, but...
Introduction to the Human Microbiota
Cystic Fibrosis: Management
Sinus disease and chronic sinusitis...

