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Related Experiment Video

Updated: May 17, 2026

Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes

Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes

Published on: September 18, 2017

Setting Snail2's pace during EMT.

Haritha Mathsyaraja¹, Michael C Ostrowski

¹Molecular, Cellular and Developmental Biology Program, Ohio State University, and the OSU Comprehensive Cancer Center, Columbus, Ohio, USA.

Nature Cell Biology

|November 8, 2012

Summary

This summary is machine-generated.

The transcription factor Elf5 regulates Snail2, a key inducer of epithelial to mesenchymal transition (EMT). This finding reveals Elf5

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Last Updated: May 17, 2026

Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes

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Published on: September 18, 2017

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Novel Metrics to Characterize Embryonic Elongation of the Nematode Caenorhabditis elegans

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Published on: March 28, 2016

Area of Science:

Molecular Biology
Cancer Research
Developmental Biology

Background:

Epithelial to mesenchymal transition (EMT) is a critical biological process.
EMT plays a significant role in embryonic development and cancer metastasis.
Understanding EMT regulators is crucial for cancer therapy development.

Purpose of the Study:

To investigate the role of transcription factor Elf5 in regulating EMT.
To identify Elf5 as an upstream regulator of Snail2, a key EMT inducer.
To elucidate Elf5's function in early cellular changes driving tumor invasiveness.

Main Methods:

Molecular and cellular biology techniques were employed.
Analysis of transcription factor interactions and gene regulation.
Investigation of pathways involved in tumor cell metastasis.

Main Results:

Elf5 was identified as a direct upstream regulator of Snail2.
Elf5 influences the earliest cellular rewiring events in EMT.
These Elf5-mediated changes are critical for tumor cell invasiveness.

Conclusions:

Elf5 is a key regulator of EMT, acting upstream of Snail2.
Elf5's role in initiating EMT contributes to cancer metastasis.
Targeting Elf5 may offer a novel therapeutic strategy for invasive cancers.