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[Diabetic cheiroarthropathy. Microcirculatory aspects].

B Guillot1, J L Poirier, C Herisson

  • 1Service de Dermatologie et Phlébologie, Centre Hospitalier Régional, Centre Hospitalier Saint-Charles, Montpellier.

Journal Des Maladies Vasculaires
|January 1, 1990
PubMed
Summary

Diabetic cheiroarthropathy involves stiffening of the fingers in diabetics. Study suggests collagen abnormalities, not just microangiopathy, may contribute to this condition.

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Area of Science:

  • Endocrinology and Metabolic Diseases
  • Rheumatology
  • Dermatology

Context:

  • Diabetic cheiroarthropathy (DCA), or limited joint mobility in the hands, is a common complication in individuals with diabetes mellitus.
  • The underlying mechanisms of DCA, involving neurogenic, vascular, and cutaneous factors, remain incompletely understood.
  • This study investigates the clinical and histological features of DCA in patients with type 1 and type 2 diabetes.

Purpose:

  • To explore the relationship between diabetic cheiroarthropathy and microvascular complications.
  • To assess capillaroscopic, photoplethysmographic, and skin biopsy findings in patients with DCA.
  • To investigate potential links between collagen metabolism abnormalities and the development of DCA.

Summary:

  • Fifteen patients with DCA underwent capillaroscopy, photoplethysmography, and skin biopsy. Common comorbidities included retinopathy, nephropathy, and neuropathy.

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  • Capillaroscopy revealed minor dystrophy in 12 patients, while microangiopathic changes were less frequent. Photoplethysmography showed abnormalities in 5 patients.
  • Histological analysis consistently demonstrated dermal collagenous fibrosis and thickened vascular basal membranes in DCA patients, suggesting a role for collagen abnormalities.

    • Impact:

    • Findings suggest that collagen metabolism abnormalities, alongside microangiopathy, may play a significant role in the pathogenesis of diabetic cheiroarthropathy.
    • This research highlights the need for further investigation into the complex interplay of factors contributing to DCA.
    • Understanding these mechanisms could lead to improved diagnostic approaches and therapeutic strategies for diabetic hand complications.