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Related Concept Videos

Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Inflammation01:38

Inflammation

Overview
Inflammation: Introduction01:28

Inflammation: Introduction

Inflammation is a fundamental, protective biological response of vascularized tissues to cellular injury, infection, or harmful stimuli. Its primary function is to eliminate the initial cause of injury, clear necrotic cells and damaged tissue, and initiate the necessary repair processes.Cardinal SignsAcute inflammation presents with classic signs. Redness results from vasodilation and increased blood flow. Heat is due to increased metabolism and circulation. Swelling results from the...
Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Acute Inflammation I: Inflammatory Response01:26

Acute Inflammation I: Inflammatory Response

Acute inflammation is a rapid, short-lived physiological response to tissue injury or infection, designed to eliminate harmful agents and initiate repair. This tightly regulated process typically lasts from minutes to several days and is triggered by factors such as microbial invasion, physical trauma, or chemical injury.Recognition and Mediator ReleaseThe inflammatory response begins when resident immune cells—such as mast cells, macrophages, and dendritic cells—detect damage-associated...

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Related Experiment Video

Updated: May 17, 2026

In vivo Imaging Method to Distinguish Acute and Chronic Inflammation
07:10

In vivo Imaging Method to Distinguish Acute and Chronic Inflammation

Published on: August 16, 2013

Inflamm-ageing.

Elisa Cevenini1, Daniela Monti, Claudio Franceschi

  • 1Department of Experimental Pathology, University of Bologna, Bologna, Italy.

Current Opinion in Clinical Nutrition and Metabolic Care
|November 8, 2012
PubMed
Summary
This summary is machine-generated.

Inflamm-ageing, chronic inflammation in aging, drives age-related diseases. Targeting inflammation via gut microbiota and nutrition can promote healthy aging and extend lifespan.

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Last Updated: May 17, 2026

In vivo Imaging Method to Distinguish Acute and Chronic Inflammation
07:10

In vivo Imaging Method to Distinguish Acute and Chronic Inflammation

Published on: August 16, 2013

Assessing Leukocyte-endothelial Interactions Under Flow Conditions in an Ex Vivo Autoperfused Microflow Chamber Assay
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Assessing Leukocyte-endothelial Interactions Under Flow Conditions in an Ex Vivo Autoperfused Microflow Chamber Assay

Published on: December 30, 2014

Area of Science:

  • Gerontology
  • Immunology
  • Molecular Biology

Background:

  • Inflamm-ageing, a chronic low-grade inflammation, is central to aging and age-related diseases.
  • The 'diseasome of inflamm-ageing' links major age-related pathologies through shared inflammatory pathways.

Purpose of the Study:

  • To comprehensively review the complex interactions driving inflamm-ageing.
  • To explore the relationship between inflamm-ageing, metaflammation, and key factors like senescent cells, gut microbiota, and nutrition.

Main Methods:

  • Literature review of scientific articles on inflamm-ageing.
  • Analysis of the interplay between aging, inflammation, and health outcomes.
  • Synthesis of current knowledge on molecular and cellular mechanisms.

Main Results:

  • Inflamm-ageing significantly impacts health status across the human lifespan.
  • Gut microbiota and nutrition are identified as crucial modulators of inflammation during aging.
  • Slowing inflamm-ageing shows potential for improving health in the elderly.

Conclusions:

  • Controlling inflamm-ageing offers a strategy to counteract age-related diseases.
  • Further research is needed to elucidate the complex mechanisms of inflamm-ageing for targeted therapies.
  • Interventions targeting gut microbiota and nutrition could promote healthy aging and longevity.