Related Experiment Video
Updated: May 17, 2026
Adult and Pediatric Porcine Model of Acute Volume Overload
Published on: January 12, 2024
A pilot study of the pleth variability index as an indicator of volume-responsive hypotension in newborn infants
Soyhan Bagci1, Nicole Müller, Andreas Müller
1Department of Neonatology, Children's Hospital, University of Bonn, Adenauerallee 119, 53113 Bonn, Germany. soyhan.bagci@ukb.uni-bonn.de
Purpose:
The aim of this pilot study was to evaluate the diagnostic value of pleth variability index (PVI) to predict fluid responsiveness in newborn infants during surgery.
Methods:
PVI was continuously recorded in 29 mechanically ventilated newborn infants during surgery, and episodes of clinically indicated volume expansion (VE) (≥10 ml/kg in ≤15 min) administration were evaluated. The upper limit of the reference range for PVI in mechanically ventilated newborns was defined by the 95th percentile of all PVI values from hemodynamically stable infants.
Results:
The upper limit of the reference range of PVI was 18 %. One hundred and three VEs were evaluated in 58 sufficient VE size (SVES) episodes and 16 insufficient initial VE size (IVES) episodes requiring repeated VE; all but one fulfilled criteria of volume-responsive hypotension (VRH). The median (interquartile range) PVI value during arterial hypotension in the 73 episodes with VRH was 23 % (20-25 %); postvolume PVI was 16 % (13-18 %). In 63 of 73 VRH episodes, during-hypotension PVI values were >18 % (86 % sensitivity for VRH). The median intermediate PVI, measured between VE in IVES episodes, was significantly higher than post-VE PVI in SVES episodes [18 % (16-21 % vs. 16 % (13-18 %].
Conclusion:
This preliminary evaluation shows that PVI may indicate VRH in newborn infants during surgery.
