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Characterization of a tissue kallikrein in human prolactin-secreting adenomas
T H Jones1, C D Figueroa, C Smith
1University Department of Medicine, Northern General Hospital, Sheffield.
The Journal of Endocrinology
|February 1, 1990
Abstract:
Immunoreactive tissue kallikrein was co-localized with prolactin in all the eleven prolactin-secreting adenomas of the human anterior pituitary gland examined in this study. The intracellular distribution of immunoreactivity in the prolactin-secreting cells suggests that tissue kallikrein is located within the Golgi complex of these cells. Both the intracellular hormone-processing action and the kininogenase activity of tissue kallikrein may be of functional importance in human prolactinomas.