Piecing together the vertebrate skull
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Updated: May 17, 2026

Reverse Dissection and DiceCT Reveal Otherwise Hidden Data in the Evolution of the Primate Face
Published on: January 7, 2019
1Collège de France, 3, rue d'Ulm, 75005 Paris, France. nicole.le-douarin@college-de-france.fr
Abstract:
In a 1993 Development paper, the quail-chick chimera system was applied to decipher the embryonic origin of the bones of the head skeleton of the avian embryo. The data reported in this article, together with those from previous works, allowed us to assign a precise embryonic origin to all the bones forming the avian skull. It turned out that their major source is the neural crest, with additional contributions from the head paraxial mesoderm and the first five somites, laying to rest a long-standing debate about the origin of the skull.
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