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Updated: May 17, 2026
Creation of Abdominal Adhesions in Mice
Published on: August 27, 2016
The effect of Kombucha on post-operative intra-abdominal adhesion formation in rats
Hemmat Maghsoudi1, Hussein Benagozar Mohammadi
1Department of Surgery, Faculty of Medicine, University of Medical Sciences of Tabriz, Tabriz, Iran.
Background:
Peritoneal adhesions are fibrous bands of tissues formed between organs that are normally separated and/or between organs and the internal body wall after peritoneal injury. The aim of the study was to investigate the effect of intra-peritoneal administration of Kombucha on intra-peritoneal adhesions.
Materials And Methods:
Eighty Wistar rats were subjected to standardized lesion by scraping model and were randomly divided into two groups. Group I received no treatment, and Group II received 15 ml of Kombucha solution intra-peritoneally. On the post-operative 14th day adhesion intensity score, inflammatory cell reaction and number of adhesion bands were determined.
Results:
In the control group, there were no rats with grade 0 and I adhesions. In the group II, there were 26 rats (78.8%) with grade 0-2 adhesions. Adhesion intensity was significantly less in group II (P<0.0001). Number of adhesion bands was significantly less in group II (P<0.001).
Conclusion:
It was concluded that intra-peritoneal administration of Kombucha might be useful for preventing peritoneal adhesions.
