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Updated: May 17, 2026
Comparison of Three Different Methods for Determining Cell Proliferation in Breast Cancer Cell Lines
Published on: September 3, 2016
Role of proliferative markers in breast lesions
Asim Kumar Manna1, Swapan Pathak, Diptendra Kumar Sarkar
1Department of Pathology, IPGME&R, Kolkata, India.
Background:
Carcinoma of breast is a leading cause of death in women throughout the world. Difficulty in diagnosis occurs in routine Hematoxylin and Eosin (H&E) stained sections to differentiate premalignant lesions like epitheliosis and malignant lesions like carcinoma in situ which may affect prognosis.
Aims:
Our study was done to assess the role of proliferative markers in this field.
Materials And Methods:
In this study, total 66 cases of different breast lesions were studied by H&E stained sections as well as proliferative markers like silver staining nucleolar organizer region (AgNOR) and proliferating cell nuclear antigen (PCNA).
Results:
Statistically significant differences found in expression of proliferative markers between most of them.
Conclusion:
Study of proliferative markers help in the proper diagnosis of different breast lesions which lies in the grey zone on routine histopathology.
