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[Decabromobiphenyl : toxicological study (author's transl)].

R Millischer, F Girault, R Heywood

    Toxicological European Research. Recherche Europeenne En Toxicologie
    |May 1, 1979
    PubMed
    Summary

    Decabromobiphenyl, a flame retardant, showed low acute toxicity and no mutagenic or teratogenic effects in rat studies. High doses caused liver changes, indicating dose-dependent toxicity.

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    Editorial.

    Medical law review·2022

    Area of Science:

    • Environmental Toxicology
    • Chemical Safety Assessment
    • Flame Retardant Research

    Context:

    • Polybrominated biphenyls (PBBs) are widely used as flame retardants.
    • Understanding the toxicological profile of PBBs is crucial for risk assessment.
    • Decabromobiphenyl is a high-brominated PBB with a significant industrial presence.

    Purpose:

    • To evaluate the toxicological profile of decabromobiphenyl.
    • To determine acute and subchronic toxicity, including irritation, oral and dermal LD50, and effects of repeated exposure.
    • To assess potential teratogenic, embryotoxic, and mutagenic effects.

    Summary:

    • Decabromobiphenyl demonstrated no skin or eye irritation in rabbits.
    • Oral and dermal LD50 in rats exceeded 5 g/kg. No toxic effects were observed in a 90-day feeding study at 100 and 500 ppm, but hepatic changes occurred at 2,000 ppm.

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  • Inhalation studies showed no effect at 0.005-0.05 mg/l, with higher concentrations causing hepatic changes. Decabromobiphenyl was not teratogenic, embryotoxic, or mutagenic in rats.
  • Toxicity appears to decrease with an increasing number of bromine atoms in polybrominated biphenyl flame retardants.

    • Impact:

    • Provides critical safety data for decabromobiphenyl, informing regulatory decisions and risk management strategies.
    • Contributes to the understanding of structure-activity relationships in PBB toxicity.
    • Highlights the importance of dose and exposure route in assessing the safety of flame retardants.