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Physiological models in pharmacokinetics are instrumental in understanding the distribution and elimination of drugs within the body. These models describe the drug concentration within target organs, influenced by factors such as drug uptake, tissue volume, and blood flow. Drug uptake is governed by the partition coefficient, which signifies the drug concentration ratio in tissue to that in the blood. The blood flow rate to a specific tissue is expressed as Qt, and the rate of change in tissue...

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In Silico Clinical Trials for Cardiovascular Disease

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Published on: May 27, 2022

Editorial: engineering approaches to study cardiovascular physiology: modeling, estimation, and signal processing

Zhe Chen¹, Riccardo Barbieri

¹Neuroscience Statistics Research Lab, Department of Anesthesia Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School Boston, MA, USA ; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology Cambridge, MA, USA.

Frontiers in Physiology

|November 8, 2012

Summary

No abstract available in PubMed .

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