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Community-based perinatal research.

R Altman1, B S Schifrin, J R Shields

  • 1AMI-Tarzana Regional Medical Center, Department of Maternal-Fetal Medicine, CA 91356.

Journal of Perinatology : Official Journal of the California Perinatal Association
|March 1, 1990
PubMed
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This study explored using placental protein in blood tests to detect fetal compromise. Researchers found that community-based clinical research involving pregnant patients and private physicians is feasible and well-received.

Area of Science:

  • Perinatal research
  • Clinical obstetrics
  • Maternal-fetal medicine

Background:

  • Community-based hospitals can facilitate clinical research.
  • Collaboration between private practice physicians and researchers is achievable.
  • Patient and physician engagement is crucial for successful research.

Purpose of the Study:

  • To investigate the utility of a circulating placental protein as a biomarker for fetal compromise.
  • To assess the feasibility of conducting longitudinal clinical research in a community hospital setting.
  • To evaluate patient and physician satisfaction with research participation.

Main Methods:

  • Longitudinal study enrolling 200 unselected pregnant patients.
  • Collection of five blood samples at key gestational points (16, 20, 24, 28, 32 weeks).

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  • Inclusion of Level II ultrasound at 32 weeks, with collection of baseline, interim, and delivery data.

    • Main Results:

    • High levels of enthusiasm reported by participating patients.
    • Generally positive feedback received from physicians and their staff.
    • Demonstrated success in conducting research without direct patient or physician benefit.

    Conclusions:

    • Community-based clinical research involving private practice physicians and their patients is feasible.
    • Enhanced educational and participatory opportunities are needed for pregnant women.
    • Successful research enhances medical care and fosters physician-patient cooperation.