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Updated: May 17, 2026

Forward Genetic Approaches in Chlamydia trachomatis
Published on: October 23, 2013
Chlamydial biology and its associated virulence blockers
Delphine S Beeckman1, Leentje De Puysseleyr, Kristien De Puysseleyr
1Department of Molecular Biotechnology, Faculty of Bioscience Engineering, Ghent University , Coupure Links 653, B-9000 Ghent , Belgium.
Abstract:
Chlamydiales are obligate intracellular parasites of eukaryotic cells. They can be distinguished from other Gram-negative bacteria through their characteristic developmental cycle, in addition to special biochemical and physical adaptations to subvert the eukaryotic host cell. The host spectrum includes humans and other mammals, fish, birds, reptiles, insects and even amoeba, causing a plethora of diseases. The first part of this review focuses on the specific chlamydial infection biology and metabolism. As resistance to classical antibiotics is emerging among Chlamydiae as well, the second part elaborates on specific compounds and tools to block chlamydial virulence traits, such as adhesion and internalization, Type III secretion and modulation of gene expression.
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