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Glycaemic variability in paediatric patients with type 1 diabetes on continuous subcutaneous insulin infusion (CSII)

C Schreiver1, U Jacoby, B Watzer

  • 1Department of Paediatrics, University Hospital Rostock, Hannover, Germany.

Clinical Endocrinology
|November 9, 2012
PubMed

Insights

Children with type 1 diabetes using insulin pumps (CSII) showed lower glycaemic variability than those using multiple daily injections (MDI). This suggests CSII may offer better blood sugar control in pediatric diabetes management.

Area of Science:

  • Pediatric Endocrinology
  • Metabolic Disorders
  • Diabetes Technology

Background:

  • Type 1 diabetes (T1D) management in children requires precise glucose control.
  • Glycaemic variability is a key factor in T1D complications.
  • Continuous Subcutaneous Insulin Infusion (CSII) and Multiple Daily Insulin Injections (MDI) are primary treatment modalities.

Purpose of the Study:

  • To compare glycaemic variability between pediatric T1D patients using CSII versus MDI.
  • To investigate the association of oxidative stress markers with glycaemic variability in T1D.

Main Methods:

  • Cross-sectional observational cohort study of 48 pediatric T1D patients.
  • 3-day ambulatory continuous glucose monitoring (CGM).
  • Urine collection for oxidative stress markers (F2-isoprostanes, prostaglandin F2).
  • Glucose pentagon used to calculate glycaemic risk parameter.

Main Results:

  • CSII group had significantly lower glycaemic excursions and standard deviation of mean glucose.
  • The glycaemic risk parameter was significantly lower in CSII patients compared to MDI patients and healthy subjects.
  • No significant difference in HbA1c between CSII and MDI groups.

Conclusions:

  • Pediatric T1D patients on CSII exhibit reduced glycaemic variability and a lower glycaemic risk parameter compared to MDI users.
  • Further research is needed to determine if these improvements translate to reduced cardiovascular risk.
Abstract

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