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Evidence for Vpr-dependent HIV-1 replication in human CD4+ CEM.NKR T-cells

Tao Zhou1, Ying Dang, Jacob J Baker

  • 1Department of Microbiology and Molecular Genetics, Michigan State University, 567 Wilson Road, 2215, Biomedical and Physical Sciences Building, East Lansing, MI 48824-4320, USA.

Retrovirology
|November 9, 2012
PubMed
Summary

Human immunodeficiency virus type 1 (HIV-1) replication in NKR T cells depends on the viral protein R (Vpr). Vpr enhances HIV-1 replication from the second cycle by overcoming an early-stage replication block, independent of DCAF1 and G2 arrest.

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