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Updated: May 17, 2026

The Examination of Peroxidase-Positive Leukocytes in Semen

The Examination of Peroxidase-Positive Leukocytes in Semen

Published on: January 19, 2024

Serum zinc level and prostatic lesion.

M T Rahman¹, M A Mumu, Y Kabir

¹Department of Pathology, Anwer Khan Modern Medical College, Dhanmondi, Dhaka, Bangladesh. mtahminur@yahoo.com

Mymensingh Medical Journal : MMJ

|November 9, 2012

Summary

This summary is machine-generated.

Serum zinc levels gradually increase with benign prostatic hyperplasia (BPH), prostatic intraepithelial neoplasia (PIN), and prostate cancer. This finding suggests serum zinc may aid in evaluating prostate lesions.

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Atomic Absorbance Spectroscopy to Measure Intracellular Zinc Pools in Mammalian Cells

Atomic Absorbance Spectroscopy to Measure Intracellular Zinc Pools in Mammalian Cells

Published on: May 16, 2019

Area of Science:

Urology
Oncology
Biochemistry

Background:

Prostate diseases, including benign prostatic hyperplasia (BPH), prostatic intraepithelial neoplasia (PIN), and prostate cancer, represent significant health concerns.
The role of trace elements, such as zinc, in the pathogenesis and progression of these prostatic lesions is an area of ongoing research.

Purpose of the Study:

To investigate the association between serum zinc levels and various prostatic lesions: BPH, PIN, and prostate carcinoma.
To determine if serum zinc levels exhibit a graded increase corresponding to the severity of prostatic pathology.

Main Methods:

Serum zinc levels were quantified using a colorimetric method with an RA50 semi-autoanalyzer.
The study included 49 patients with diagnosed prostatic pathologies (BPH, PIN, carcinoma) and 30 age-matched controls without prostatic complaints.

Main Results:

A statistically significant (p<0.01) gradual increase in serum zinc levels was observed across the spectrum of prostatic lesions.
Mean serum zinc levels were 101 ± 26.15 μgm/dl in BPH, 116 ± 21.34 μgm/dl in low-grade PIN, 117 ± 20.95 μgm/dl in high-grade PIN, and 139 ± 11.09 μgm/dl in prostate carcinoma.
These findings indicate a positive correlation between serum zinc concentration and the presence and grade of prostatic lesions.

Conclusions:

Serum zinc levels demonstrate a statistically significant, gradual increase in patients with benign prostatic hyperplasia, prostatic intraepithelial neoplasia, and prostate carcinoma.
Serum zinc level estimation can serve as a valuable adjuvant tool for the routine evaluation of prostatic lesions.