Related Experiment Video
Updated: May 17, 2026
06:01
A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
Published on: August 18, 2015
Genetics of ischemic stroke: Indian perspective
1Department of Neurology, Nizams Institute of Medical Sciences, Punjagutta, India. subashkaul@hotmail.com
Neurology India
|November 9, 2012
Summary
Genetic variations in the phosphodiesterase 4D (PDE4D) gene are linked to ischemic stroke risk. This study confirms PDE4D as a predisposition gene for stroke in both South and North Indian populations.
Area of Science:
- Genetics
- Neurology
- Cardiovascular Diseases
Background:
- Stroke is a leading cause of disability and mortality worldwide.
- Inherited genetic factors contribute to stroke pathogenesis.
- Identifying genetic variants may lead to novel preventive therapies.
Purpose of the Study:
- To investigate the genetic contribution to ischemic stroke risk in the Indian population.
- To explore the role of the phosphodiesterase 4D (PDE4D) gene in ischemic stroke.
- To assess if PDE4D is a predisposition gene for stroke in India.
Main Methods:
- Candidate gene association study.
- Analysis of genetic variants in the PDE4D gene.
- Comparison of allele frequencies between stroke patients and controls.
Main Results:
- The phosphodiesterase 4D (PDE4D) gene was identified as a significant risk factor for ischemic stroke.
- Positive replication studies confirm the association of PDE4D with stroke.
- PDE4D is implicated in ischemic stroke predisposition in both Southern and Northern Indian populations.
Conclusions:
- The PDE4D gene plays a role in the genetic predisposition to ischemic stroke in India.
- Further research into PDE4D could inform novel preventive strategies for stroke.
- Genetic factors are crucial in understanding and managing stroke risk.
Related Concept Videos
01:15Ischemic Stroke ll: Pathophysiology
An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
01:15Ischemic Stroke l: Introduction
Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
01:29Hemorrhagic Stroke ll: Pathophysiology
A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
01:17Hemorrhagic Stroke l: Introduction
A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
01:17Ischemic Heart Disease: Overview
Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and narrowing...
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and narrowing...
01:26Transient Ischemic Attack l: Introduction
A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...