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Published on: May 2, 2025
[Proteomics analysis of mandibles in type 2 diabetic rat]
Ying Li1, Hong-chen Liu, Yan Lv
1Institute of Stomatology, General Hospital of Chinese PLA, Beijing 100853, China. liying0914@gmail.com
Purpose:
To investigate the differentially expressed proteins in mandible between normal rats, and type 2 diabetic rats.
Methods:
Wistar rats and Goto-Kakizaki (GK) rats were selected as normal controls and experimental rats respectively. Weight and blood glucose were measured before sacrificed. The mandibles of each group were removed at the same time. After protein extraction, differentially expressed proteins were separated by two-dimensional gel electrophoresis (2-DE) and identified by MALDI-TOF/TOF. Statistical analysis was performed using SPSS 15.0 software package.
Results:
Blood glucose levels of the experimental group were significantly higher than that of the control group(P<0.05). The weights of the two groups were not significantly different. 20 proteins were differentially expressed at least 3-fold between GK rats and Wistar rats. Of the 20 proteins, 5 proteins were more than 20-fold different between the two groups. The 5 proteins fell into 3 functional categories as follows: metabolism, binding proteins, and signal transduction.
Conclusions:
The differentially expressed proteins of mandible between GK rats and Wistar rats may be new targets for investigating the mechanisms of the effect of type 2 diabetes on mandible.
