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Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
[Meta analysis of association between TNF-α-308 polymorphism and periodontitis in Chinese Han population]
Cheng-jie Xie1, Lei Chen, Fang-li Tong
1Department of Periodontology, Guangdong Provincial Stomatological Hospital & Affiliated Hospital of Southern Medical University, Guangzhou 510280, Guangdong Province, China. chengjie.xie@gmail.com
Purpose:
To assess the association between TNF-α-308 polymorphism and periodontitis in Chinese Han population.
Methods:
Articles published between 1994 and 2011 were searched in the fulltext database of CNKI, Chinese Biomedical Literature Database, Wanfang Database and PubMed. Case-control studies on TNF-α-308 polymorphism and periodontitis were searched up to Feb.,2011, including articles in Chinese and in English. Meta analysis was performed to evaluate the prevalence of Allele 2 between case group and control group.
Results:
Five studies were entered into Meta analysis,with 494 cases and 501 controls . No significant heterogeneity was found among the studies(P=0.38); the pooled OR value of allele 2 was 2.12(95% CI 1.57-2.86), with significant difference(P<0.01).
Conclusion:
Meta analysis showed that TNF-α-308 polymorphism was associated with periodontitis in Chinese Han population.
