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Updated: May 17, 2026

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity
Published on: April 11, 2019
Protective immunity from a germinal center sanctuary
Harriet L Robinson1, Rama Rao Amara
1Geovax, Smyrna, GA, USA. hrobinson@geovax.com
Abstract:
A new study provides mechanistic insights into how live attenuated simian immunodeficiency virus (SIV) vaccines (LAVs) can protect monkeys from infection with pathogenic SIV. The authors show that replicating LAVs stimulate a protective immune response from a safe haven in the germinal centers of lymph nodes (pages 1673-1681).
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