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Updated: May 17, 2026
A Protein Microarray Assay for Serological Determination of Antigen-specific Antibody Responses Following Clostridium difficile Infection
Published on: June 15, 2018
Quantitative fecal lactoferrin in toxin-positive and toxin-negative Clostridium difficile specimens
P Rocco LaSala1, Tariq Ekhmimi, A Kate Hill
1Department of Pathology, Robert C. Byrd Health Sciences Center, West Virginia University, and Clinical Laboratory, West Virginia University Healthcare, Morgantown, West Virginia, USA. plasala@hsc.wvu.edu
Abstract:
Quantitative fecal lactoferrin was measured in 112 patients tested for toxigenic Clostridium difficile using glutamate dehydrogenase (GDH) and toxin immunoassays combined with tcdB PCR. Lactoferrin levels were higher in the GDH-positive/toxin-positive group (79 μg/ml) than in the GDH-positive/toxin-negative/PCR-positive (21 μg/ml) and the GDH-negative groups (13 μg/ml). Differences in fecal lactoferrin levels suggest variable presence or severity of C. difficile infection among toxin-positive and toxin-negative patients.
