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Related Concept Videos

Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...

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Updated: May 17, 2026

High-throughput Protein Expression Generator Using a Microfluidic Platform
09:26

High-throughput Protein Expression Generator Using a Microfluidic Platform

Published on: August 23, 2012

Microfluidic devices for high-throughput proteome analyses.

Tzu-Chiao Chao1, Nicole Hansmeier

  • 1Department of Chemistry and Biochemistry, Arizona State University, Tempe, AZ, USA.

Proteomics
|November 9, 2012
PubMed
Summary
This summary is machine-generated.

Microfluidic devices offer enhanced proteomics analysis with reduced sample use and faster results. This review highlights advancements in integrating these bioanalytical platforms for automated, high-throughput proteomic workflows.

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Last Updated: May 17, 2026

High-throughput Protein Expression Generator Using a Microfluidic Platform
09:26

High-throughput Protein Expression Generator Using a Microfluidic Platform

Published on: August 23, 2012

Digital Microfluidics for Automated Proteomic Processing
10:55

Digital Microfluidics for Automated Proteomic Processing

Published on: November 6, 2009

Fast Enzymatic Processing of Proteins for MS Detection with a Flow-through Microreactor
09:49

Fast Enzymatic Processing of Proteins for MS Detection with a Flow-through Microreactor

Published on: April 6, 2016

Area of Science:

  • Biotechnology
  • Analytical Chemistry
  • Bioengineering

Background:

  • Microfabricated bioanalytical platforms are gaining traction for revolutionizing biological analytics.
  • Key advantages include design flexibility, low sample consumption, rapid analysis, and minimized manual handling, crucial for proteomics.
  • The development of integrated chip-based microfluidic devices promises automated workflows from cell cultivation to mass spectrometry (MS)-based proteome analysis.

Purpose of the Study:

  • To review recent developments and strategies for enabling and integrating proteomic workflows into microfluidic devices.
  • To highlight the potential of microfluidics to improve the reliability, reproducibility, and throughput of proteomic investigations.
  • To discuss the progress made in translating proteomic sample handling and separation steps into microfluidic formats.

Main Methods:

  • Review of recent literature on microfluidic devices for proteomics.
  • Analysis of strategies for integrating various proteomic workflow steps (e.g., sample handling, separation) into microfluidic platforms.
  • Focus on advancements leading towards fully automated, chip-based proteomic analysis.

Main Results:

  • Significant improvements have been made in adapting proteomic sample handling and separation techniques for microfluidic applications.
  • While fully integrated devices are not yet routine, many components and processes have been successfully translated to microfluidic formats.
  • Microfluidic approaches demonstrate potential for reducing sample volume, minimizing manual steps, and increasing analysis speed.

Conclusions:

  • Microfluidic technology is advancing the field of proteomics by enabling more efficient and automated workflows.
  • Continued development in microfluidic device integration is key to realizing the full potential of rapid, high-throughput proteomic analysis.
  • These platforms are poised to significantly enhance the reliability and reproducibility of proteomic studies.