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Uncontrolled arterial hypertension in primary care--patient characteristics and associated factors
Corinne Chmiel1, Mathyas Wang, Oliver Senn
1Division of Internal Medicine, University Hospital of Zurich and Institute of General Practice, University of Zurich, Switzerland. corinne.chmiel@usz.ch
Insights
In Swiss primary care, high BMI and smoking are key factors for uncontrolled high blood pressure. Optimal pharmacological treatment and risk factor management are crucial for better blood pressure control.
Area of Science:
- Cardiology
- Primary Care Medicine
- Hypertension Research
Background:
- Arterial hypertension management is predominantly a primary care responsibility.
- Assessing uncontrolled hypertension and its determinants in Swiss primary care is essential.
Purpose of the Study:
- To evaluate patient characteristics associated with uncontrolled arterial hypertension.
- To identify determinants of uncontrolled hypertension in a Swiss primary care setting.
Main Methods:
- Analysis of baseline data from 122 adult patients in the "CoCo" trial (Colour-coded Blood Pressure Control).
- Inclusion criteria: uncontrolled hypertension (>140/90 mm Hg).
- Patient and general practitioner characteristics were analyzed for associations with blood pressure.
Main Results:
- Key patient demographics: median age 64, 50% male, median BMI 28.3 kg/m², 21.5% smokers.
- High prevalence of home blood pressure measurement (65.6%) and pharmacological treatment (88.5%), with 41.8% on monotherapy.
- Independent predictors for elevated systolic blood pressure included BMI, smoking, and age.
- Age and number of antihypertensive substances were inversely correlated with diastolic blood pressure.
Conclusions:
- Smoking and high BMI are significant independent factors contributing to elevated blood pressure in uncontrolled hypertension.
- Findings underscore the need for effective pharmacological treatment and robust risk factor modification.
- Suboptimal treatment intensification suggests room for improvement in antihypertensive regimens.
Principles:
Most patients with arterial hypertension are treated in primary care. The objective is to assess characteristics of patients with uncontrolled arterial hypertension and its associated determinants in Swiss primary care.
Method:
Data on 122 adult patients with uncontrolled hypertension (mm Hg >140 systolic and/or >90 diastolic) was collected from the baseline data of the on-going randomised controlled "CoCo" trial: Colour-coded Blood Pressure Control. Patient and general practitioner characteristics were analysed to investigate the relationship between BP and patient characteristics.
Results:
From October 2009 to March 2011 30 general practitioners recruited 122 patients; median age 64 years (IQR 54.8-72), 50% male, median BMI 28.3 kg/m2 (IQR 25.3-31.7), 21.5% smokers. 65.6% performed home blood pressure measurement, 88.5% received pharmacological treatment, 41.8% mono-therapy. Most frequent dual drug combinations: diuretics/angiotensin-receptor-blockers (33.3%), angiotensin-converting-enzyme-inhibitors/beta blockers (both 28.1%). BMI, smoking and age were independent predictors for elevated systolic blood pressure when controlled for gender, home blood pressure measurement, education, pulse rate and number of antihypertensive substances. We found a significant non-linear association between systolic blood pressure and number of antihypertensive substances. Age and any amount of antihypertensive substances were independently and inversely correlated with diastolic blood pressure. The findings did not change when additionally controlled for general practitioner clustering effect.
Conclusion:
Smoking and high BMI are strong and independent factors associated with higher blood pressure levels in patients with uncontrolled arterial hypertension. A high rate of monotherapy and a decrease in the incremental gain on blood pressure control when more antihypertensive agents are used highlight the importance of adequate pharmacological treatment as well as risk factor control.
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